Sesderma Sesretinal Anti Aging Cream Gel 50ml is a sophisticated retinaldehyde-based anti-ageing treatment from the Spanish dermatological skincare specialist Sesderma. The fast-absorbing gel-cream pairs encapsulated retinaldehyde with bakuchiol (a "natural retinoid"), bio-retinoid plant peptides, glycolic and mandelic AHAs and hyaluronic acid — delivering visible smoothing, renewal and brightening with less of the irritation associated with traditional retinol.
About Sesderma
Sesderma is a Spanish dermatological skincare brand founded in 1989 by dermatologist Dr Gabriel Serrano in Valencia. The brand pioneered liposome encapsulation in cosmeceutical skincare — a delivery technology that allows actives to penetrate the skin more effectively while reducing irritation. The Sesretinal range is the brand's retinal-led anti-ageing line, sitting at the intersection of clinical anti-ageing skincare and gentle daily wearability.
Key actives
- Retinal (Retinaldehyde): a fast-converting form of vitamin A — closer in activity to prescription tretinoin than standard retinol, but better tolerated.
- Bakuchiol: a plant-derived "natural retinoid" — supports skin smoothing without the side effects associated with retinoids.
- Nicotiana Benthamiana SH-Polypeptide-7: a bio-engineered peptide — provides growth-factor-like anti-ageing support.
- Glycolic and Mandelic Acid (AHAs): chemical exfoliants — smooth the skin's surface and support more even tone.
- Sodium Hyaluronate (Hyaluronic Acid): draws moisture into the skin for plumper, hydrated comfort.
- Niacin (Vitamin B3): supports a more even-toned, brighter-looking complexion.
- Glucosamine HCl + Copper Sulfate: support skin renewal and the appearance of a healthier complexion.
- Goji Berry (Lycium Barbarum) Extract: antioxidant-rich botanical.
- Glycyrrhetinic Acid (Liquorice-derived): soothes and helps even tone.
Key benefits
- Visibly smooths fine lines and wrinkles thanks to retinaldehyde and bakuchiol working together.
- Brightens and evens skin tone — helps with the look of pigmentation and dullness.
- Refines skin texture with built-in AHA exfoliation.
- Hydrates and plumps the skin with hyaluronic acid.
- Lightweight gel-cream texture — comfortable for combination, oily and even sensitive skin types.
- Generally better tolerated than pure retinol while delivering comparable results.
Who it's for
Sesretinal Cream Gel is for adults — typically from around 35 onwards — who want a serious anti-ageing treatment with retinoid-level results but who find pure retinol irritating. The lightweight gel-cream texture makes it well-suited to combination and oily skin. The dual retinaldehyde + bakuchiol combination also makes it a sensible "transitional" retinoid for those new to vitamin A skincare.
How to use
- Best used in the evening, after cleansing and toning.
- Dispense a pea-sized amount onto the fingertips.
- Apply across the face and neck in upward, outward strokes — avoiding the eye area.
- Allow to absorb fully before applying any night cream over the top.
- When first using, start with 2–3 applications per week and build up to nightly as the skin adapts.
- Always wear a broad-spectrum SPF in the daytime — retinoids and AHAs increase the skin's sensitivity to UV.
Specifications
- Size: 50ml
- Format: Cream gel — lightweight anti-ageing treatment
- Range: Sesretinal
- Targets: Wrinkles, dullness, uneven tone, loss of firmness
- Brand: Sesderma
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