Payot Lisse Retinol Renewing Night Serum 15ml is a high-concentration overnight retinol treatment from the French dermo-cosmetic house, formulated as a serum-in-oil with 0.3% pure retinol. Designed as a 30-day intensive course, it works while you sleep to soften the look of even deep wrinkles, smooth uneven texture and restore radiance, while a blend of organic plant oils keeps the formula comfortable on skin that often finds retinol drying.
About Payot
Payot is a French skincare house founded in Paris in 1920 by Dr Nadia Payot, one of the first women in Europe to qualify as a medical doctor specialising in skin. Her facial method — the original "Payot 42 movements" — became a Parisian institution, and the brand has remained closely tied to dermatology and clean, ingredient-led formulation ever since. The Lisse range targets visible wrinkles, with the Retinol Renewing Night Serum sitting as the line's most concentrated nightly treatment.
Key ingredients
- Pure retinol (0.3%): the gold-standard anti-ageing active, encouraging skin renewal to soften wrinkles and refine texture
- Organic jojoba, macadamia & sesame oils: nourish and soften, helping to offset the dryness retinol can cause
- Baobab (Adansonia digitata) seed oil: rich in essential fatty acids and antioxidants for skin comfort
- Aster tripolium extract: a sea-aster active that contributes to a smoother, more even complexion
- Vitamin E (tocopherol): antioxidant that helps protect the formula and skin from oxidative stress
Key benefits
- Visibly fills in even deep, marked wrinkles with continued use
- Refines skin texture and improves overall radiance
- 98% ingredients of natural origin in a fragrance-free formula for better tolerance
- Comforting serum-in-oil texture that absorbs without leaving a greasy film
Who it's for
Best for those concerned with fine lines, deeper wrinkles or uneven, lacklustre skin texture, and for retinol users who find lighter aqueous serums too drying. The fragrance-free, oil-rich format makes it a useful option for normal, dry and mature skin types in particular. Not for use during pregnancy or breastfeeding.
How to use
- Use in the evening only, on clean skin.
- Warm two or three drops between the fingertips and press gently across the face and neck, avoiding the immediate eye area.
- Follow with your usual night cream once the serum has absorbed.
- Build up frequency gradually if you are new to retinol — start with two or three nights a week, then increase as tolerated.
- Use SPF 30 or higher every morning during and after the 30-day course.
Specifications
- Size: 15ml
- Format: Serum-in-oil with 0.3% pure retinol
- Skin type: Suitable for normal, dry and mature skin (including sensitive)
- Brand: Payot Paris
- Range: Lisse



