Sesderma Activating Factor G Renew Collagen Cream 50ml is a high-strength growth-factor face cream from the Spanish dermo-cosmetic brand. Built around the brand's seven plant-derived biotechnological growth factors plus mimetic peptides, Malus domestica stem cells and ergothioneine — designed for visibly more rejuvenated, firmer-feeling skin.
About Sesderma
Sesderma is the Spanish dermo-cosmetic skincare brand founded in Valencia in 1989 by dermatologist Dr Gabriel Serrano Sanmiguel. Best known for its liposomal delivery technology, the brand operates at the dermatologist-counter end of the market — with the Factor G franchise as its signature anti-ageing growth-factor pillar.
Key ingredients
- 7 Plant-Based Biotechnological Growth Factors — including TGF-b2, EGF, GM-CSF, TIMP-2, TRX and IGF-1, derived through Nicotiana benthamiana technology.
- Malus Domestica Fruit Cell Culture Extract — apple-derived stem cell technology.
- Mimetic Peptides — Palmitoyl Tripeptide-5 and Caproyl Tetrapeptide-3.
- Centella Asiatica Extract — for soothing, conditioning support.
- Ergothioneine, Quercetin and Resveratrol — antioxidant complex.
- Vitamin E (Tocopherol Acetate) — antioxidant support.
Who it's for
Anyone in their 30s and beyond targeting the visible signs of ageing — particularly fine lines, loss of firmness and lacklustre skin. A natural pick for users already familiar with growth-factor and peptide skincare, and those wanting a dermo-cosmetic-brand alternative to clinical aesthetic-medicine routines.
How to use
- Cleanse and tone the skin as usual.
- Apply your serum first, if using; allow to absorb.
- Take a small amount of the cream and apply evenly to face and neck in upward strokes.
- Use morning and evening for an everyday rejuvenating step.
- Always follow with a broad-spectrum SPF in the morning.
Specifications
- Brand: Sesderma
- Range: Factor G Renew
- Product: Activating Factor G Renew Collagen Cream
- Format: 50ml jar
- Use: Morning and evening



