Perricone MD Essential Fx Acyl-Glutathione Rejuvenating Moisturizer 30ml is a velvety, anti-ageing day-and-night cream built around Perricone MD's signature Acyl-Glutathione molecule — a stabilised, skin-penetrating form of glutathione, the body's master antioxidant. Layered over a Vitamin F seed-oil blend (flax, chia and macadamia), the formula targets deep creases, dryness and loss of elasticity in mature, dehydrated skin.
Key ingredients
- Acyl-Glutathione — Perricone MD's patented form of glutathione (a 3-amino-acid antioxidant). Helps replenish and protect fragile, ageing skin and visibly soften etched creases.
- Vitamin F Blend — flax, chia and macadamia seed oils that rebuild the moisture barrier and restore suppleness.
- Rose extract — gives the cream its natural floral scent and adds a soothing, comforting feel on application.
Key benefits
- Deeply moisturises dry, tight skin without leaving a greasy residue
- Visibly softens deep wrinkles and the appearance of etched creases over time
- Plumps and firms the skin's surface for a smoother, more lifted look
- Restores the moisture barrier via the omega-rich seed-oil blend
In a brand-conducted 28-day consumer study of 102 women, 87% said their skin felt deeply moisturised and 75% saw improvement in elasticity and the look of wrinkles.
About Perricone MD
Perricone MD is a US clinical skincare brand founded by Dr Nicholas Perricone, a board-certified dermatologist whose research focuses on inflammation as a driver of skin ageing. The brand's Essential Fx range was built around Acyl-Glutathione — a stable, lipid-soluble form of glutathione developed to deliver the antioxidant deeper into the skin than conventional glutathione formulations.
Who it's for
Best for mature, dry or dehydrated skin showing visible wrinkles, loss of elasticity or a compromised barrier. Layer it over your serum at the end of a routine — this is the moisturising, finishing step rather than a stand-alone treatment. Suitable for normal-to-dry skin types; very oily or acne-prone skin may prefer a lighter formulation.
How to use
- Cleanse and tone the skin as usual.
- Apply any serums or concentrates first and let them absorb.
- Massage a small amount of the moisturiser onto the face and neck using gentle upward strokes.
- Use both morning and evening for daily wear.
Specifications
- Size: 30ml (1 fl oz)
- Skin type: Normal to dry; mature
- Free from: Parabens, sulfates, gluten, soy, nuts
- Other: Vegan and cruelty-free
- Brand: Perricone MD
Frequently asked questions
What is Acyl-Glutathione, and why is it different from regular glutathione?
Acyl-Glutathione is Perricone MD's patented, lipid-soluble form of glutathione. Standard glutathione struggles to penetrate the skin barrier; the acyl modification allows it to pass through more easily, delivering antioxidant support deeper in the skin where it can support cellular function.
How does it differ from the Intensive Overnight version?
The Rejuvenating Moisturizer is the day-and-night cream — lighter, fast-absorbing, and designed to wear under makeup. The Intensive Overnight Moisturizer is a richer, sleep-mask style formula intended to be worn alone at night. Many users alternate the two depending on the season or how dehydrated their skin feels.
Is the moisturiser suitable for sensitive skin?
The formula is parabens-, sulfate-, soy-, nut- and gluten-free, and the brand classifies it as suitable for sensitive skin. As with any new active product, do a 24-hour patch test on the inner arm before applying to the face if you have a history of reactivity.
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